INTERACTION OF CAT GENOMIC DNA WITH MANGANESE(II) p-AMINOBENZOATE COMPLEX
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چکیده
The complex of bis-(p-aminobnzoato)tetraquamanganese(II) was synthesized according to the literature method. The interaction between bis-(p-aminobnzoato)tetraquamanganese(II) and cat genomic DNA was studied by gel electrophoresis, fluorescence spectroscopy, UV-visible and viscosity methods. The results suggest that the complex binds with DNA by intercalating through the ligand. The intrinsic binding constant Kb of [Mn(p-H2N-C6H4COO)2] .4H2O (MnPAB) was determined as 2.9 x 10 M . The binding constant shows that the complex binds to DNA. Also all the other experimental results proved that [Mn(p-H2N-C6H4COO)2] .4H2O could attach to DNA mainly by intercalative binding mode.
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تاریخ انتشار 2010